Showing posts with label cancer stem cell. Show all posts
Showing posts with label cancer stem cell. Show all posts

Cannabis and coconut oil make powerful mixture to kill cancer cells

Humans have cultivated and used the flowering tops of the female cannabis plant, known colloquially as marijuana since history was recorded. Archaeologists in Central Asia even found over 2 pounds of cannabis in a 2,700-year-old grave of a shaman.
Written and pictorial evidence of cannabis use is scattered throughout numerous cultures indicating a wide acceptance and use of the plant for thousands of years.

Drug Classification Halts Use

cannabis
Federal prohibitions outlawing the therapeutic and recreational use of cannabis were first imposed by Congress with the Marijuana Tax Act of 1937. Later, the plant’s organic compounds (cannabinoids) were classified as a Schedule I substance under the Controlled Substances Act of 1970.
This classification puts the plant in the same pool as heroin and states that cannabis possesses “a high potential for abuse … no currently accepted medical use … [and] a lack of accepted safety for the use of the drug … under medical supervision.”
In contrast, cocaine and methamphetamine – illegal for recreational use, may be consumed under a doctor’s supervision and are classified as Schedule II drugs. Examples of Schedule III and IV drugs include anabolic steroids and Valium. Analgesics that contain codeine are defined by law as Schedule V drugs, the most lenient classification.

In Support of Therapeutic Use

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Federal lawmakers continue to use the dated drug classification as a means to defend criminalization of marijuana. However, there appears to be a very little scientific basis for the categorization of the plant. As its prohibition has passed 75 years, researchers continue to study the therapeutic properties of cannabis.
There are over 20,000 published reviews and studies in a scientific literature that pertain to the cannabis plant and its cannabinoids, almost one-third of these have been published in the last 4 years. A keyword search on PubMed Central (the US government library of peer-reviewed scientific research) shows 2,100 studies alone since 2011.
Modern culture is now catching up on what our ancestors knew, and public opinion and relaxing state legislation are leading the way for more people to use medicinal marijuana for a wide number of medical conditions. At present, marijuana for medical purposes is legal in 20 states and the District of Columbia.
While the debate continues to boil at both state and federal levels, there has been a strong and growing trend of acceptance related to the growing body of scientific evidence indicating that marijuana may indeed contain some powerful medicinal properties that we would be foolish to overlook.
Joycelyn Elders, MD, former US Surgeon General, wrote the following in a March 26, 2004, article titled “Myths About Medical Marijuana,” published in the Providence Journal:
“The evidence is overwhelming that marijuana can relieve certain types of pain, nausea, vomiting and other symptoms caused by such illnesses as multiple sclerosis, cancer, and AIDS — or by the harsh drugs sometimes used to treat them. And it can do so with remarkable safety. Indeed, marijuana is less toxic than many of the drugs that physicians prescribe every day.”
Ray Cavanaugh, Ph.D., National Director of the American Alliance for Medical Cannabis (AAMC), wrote the following in a 2002 article titled “The Plight of the Chronically Ill,” posted on the AAMC website:
“Many of the chronically ill have successfully sought relief with the use of medical cannabis, an age-old remedy that now shows real scientific efficacy. Hundreds of thousands of the sick have replaced disabling narcotics and other psychotropic medications with nontoxic and benign cannabis. The anecdotal evidence is overwhelming.
Folks with spinal injuries able to give up their walkers, AIDS patients able to gain weight and keep their medications down, cancer patients finding relief from the terrible nausea of chemotherapy, chronic pain patients once again functional with their consciousness restored from narcotic lethargy, and folks once disabled from crippling psychiatric disorders and addictions, returned to sanity and society with the assistance of a nontoxic herb with remarkable healing powers.”
The American Nurses Association (ANA) wrote the following in its Mar. 19, 2004 “Position Statement: Providing Patients Safe Access to Therapeutic Marijuana/Cannabis,” posted on the ANA website:
“The American Nurses Association (ANA) recognizes that patients should have safe access to therapeutic marijuana/cannabis. Cannabis or marijuana has been used medicinally for centuries. It has been shown to be effective in treating a wide range of symptoms and conditions.”
Researchers at the University of California Center for Medicinal Cannabis Research announced findings from a number of randomized, placebo-controlled clinical trials on the medical utility of inhaled cannabis in 2010.
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The studies used the FDA ‘gold standard’ clinical trial design and reported that marijuana should be the “first line of treatment” for patients suffering from neuropathy and other serious illnesses.
Neuropathy is a type of pain associated with diabetes, cancer, spinal cord injuries, HIV/AIDS and other debilitating conditions. The trials indicated that marijuana controlled pain as good or better than available medications.
Scientists continue to study the effectiveness of cannabinoids all over the world. In Germany, there have been over 37 controlled studies, with over 2,500 subjects, assessing the safety and efficacy of marijuana, since 2005. In contrast, most FDA-approved drugs go through far fewer trials with fewer subjects but are approved for use.
The research on cannabis has shifted from studying its ability to alleviate symptoms of a disease such as nausea associated with chemotherapy to its potential role in modifying disease. Medical marijuana has been shown to slow the onset of Alzheimer’s disease and moderate autoimmune disorders including multiple sclerosis, inflammatory bowel disease, and rheumatoid arthritis.

Cannabis and Coconut Oil

Medical marijuana capsules infused in coconut oil are an alternative way to therapeutically use cannabis without having to inhale it through smoking. Infusing cannabis into coconut oil also allows for easy entry into the liver where it can be rapidly processed.
Coconut oil is used because of its high amount of essential fatty acids which makes it a good binding agent for the cannabinoids. Not to mention its amazing health properties. Half of the fat in coconut oil is comprised of a fat that is not frequently found in nature, lauric acid.
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Lauric acid has been called a “miracle” ingredient due to its health-promoting capabilities and is present in a mother’s milk. In fact, it can be found in only three dietary sources—small amounts in butterfat and larger amounts in palm kernel and coconut oil.
In the body, lauric acid is converted to monolaurin, which is a potent antiviral, antibacterial and antiprotozoal substance. Because monolaurin is a monoglyceride, it can destroy lipid-coated viruses including measles, influenza, HIV, herpes and a number of pathogenic bacteria.

Testimony – A Success Story

While many remain suspicious of the therapeutic benefits of cannabis, Stan and Barb Rutner are convinced of its efficacy. This couple has stood in the face of cancer a number of times and survived to learn from their experiences.
Barb had two bouts of breast cancer and Stan were diagnosed 20 years ago with non-Hodgkin lymphoma which, after treatment, disappeared. However, in 2011, it returned. Cancerous nodes in his lungs were diagnosed and later he was told that the cancer was in his brain. The outlook was grim indeed.
As he went through the harsh treatment of chemotherapy and radiation, Stan and his family wanted to find a natural solution that would help improve his quality of life and even prolong it. Hearing that cannabis was effective in helping with the pain and other effects of chemotherapy for cancer patients they were more than open to give it a try. According to Stan and Barb, medical cannabis was the golden ticket.
The Rutners daughter, Corinne and her husband did some research and it was decided that daytime cannabis capsule infused in coconut oil would be a good choice. After two weeks of taking the capsule, Stan was able to give up his oxygen tank that he was tied to around the clock. He began to gain weight, sleep better and get stronger overall. After several months, a brain scan revealed that Stan was completely cancer free.
The Rutners are convinced that cannabis works as an anti-cancer medicine. According to John, the Rutners son-in-law:
“There is no doubt in my mind that cannabis pulled my father-in-law out of the wasting stages of cancer and enabled him to gain strength and in turn fight this horrible cell malfunction with success. While many would say that the chemo and radiation could have played a part, he would never have lived long enough to find out without cannabis oil.”
https://www.youtube.com/watch?v=bHBPKtnvX1U 

600 Reasons Turmeric May Be The World’s Most Important Herb

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By Sayer Ji • Originally published on Greenmed.info
There is a medicinal spice so timelessly interwoven with the origins of human culture and metabolism, so thoroughly supported by modern scientific inquiry, as to be unparalleled in its proven value to human health and well-being.
Indeed, turmeric turns the entire drug-based medical model on its head. Instead of causing far more side effects than therapeutic ones, as is the case for most patented pharmaceutical medications, turmeric possesses hundreds of potential side benefits, having been empirically demonstrated to positively modulate over 160 different physiological pathways in the mammalian body.
While no food or herb is right for everyone, and everything has the potential for unintended, adverse side effects, turmeric is truly unique in its exceptionally high margin of safety vis-à-vis the drugs it has been compared with, e.g. hydrocortisoneibuprofenchemotherapy agents. Furthermore, nothing within the modern-day pharmaceutical armamentarium comes even remotely close to turmeric’s 6,000 year track record of safe use in Ayurvedic medicine.
Despite its vast potential for alleviating human suffering, turmeric will likely never receive the FDA stamp of approval, due to its lack of exclusivity, patentability and therefore profitability. Truth be told, the FDA’s “gold standard” for proving the value of a prospective medicinal substance betrays the age old aphorism: “he who owns the gold makes the rules,” and unless an investor is willing to risk losing the 800+ million dollars that must be spent upfront, the FDA-required multi-phased double-blind, randomized clinical trials will not occur. For additional details on this rather seedy arrangement read my article on the topic: Why The Law Forbids The Medicinal Use of Natural Substances.
At GreenMedInfo.com, we have reviewed over 5,000 study abstracts from the National Library of Medicine’s bibliographic database known as MEDLINE and have discovered over 600 potential health benefits of turmeric, and/or its primary polyphenol known as curcumin. These can be viewed on our turmeric research page which is dedicated to disseminating the research on the topic to a larger audience.
Some of the most amazing demonstrated properties include:
Again, what is so amazing is not that turmeric may have value in dozens of health conditions simultaneously, or that it may improve conditions that are completely resistant to conventional treatment, but that there are over six hundred additional health conditions it may also be valuable in preventing and/or treating. Consider also the fact that turmeric grows freely on the Earth, and you will understand why its very existence threatens billions of dollars in pharmaceutical industry revenue.
Learn more about this research in the video below (keeping in mind that it is several years old and needing some updating), and please spread the information to others who may benefit from learning more on the topic.

From Ocean Robbins, Food Revolution Network CEO:

Many of our members have been asking how much curcumin to take, how to take it in a bioavailable form, and where to get curcumin from a source they can trust. The challenge with taking full advantage of the curcumin in turmeric is low bioavailability. Personally, I love mixing fresh and dried turmeric into all sorts of foods – and I always try to include black pepper with it, because studies show that piperine (found in black pepper) helps to increase absorbability. But now Quantum Wellness Botanical Institute has developed a curcumin supplement that includes a potent delivery enhancer (made using organic lecithin and organic turmeric oil) which they say has been found to increase bioavailability by 500%. Their supplement is 100% vegetarian, organic, soy free and non-GMO. Click here if you’d like to find out more.

Ginger: 10,000x Stronger Than Chemo In Cancer Research Model

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Study: Ginger fights cancer
By Sayer Ji • Originally published on GreenMedInfo.com
A new study reveals ginger contains a pungent compound that could be up to 10,000 times more effective than conventional chemotherapy in targeting the cancer stem cells at the root of cancer malignancy.
A new study published in PLoS reveals a pungent component within ginger known as 6-shogaol is superior to conventional chemotherapy in targeting the root cause of breast cancer malignancy: namely, the breast cancer stem cells.
As we have discussed in greater detail in a previous article titled, “Cancer Stem Cells: The Key To Curing Cancer,” cancer stem cells are at the root of a wide range of cancers, not just breast cancer, and are sometimes referred to as “mother cells” because they are responsible for producing all the different “daughter” cell types that makeup the tumor colony. While cancer stem cells only constitute between .2 and 1% of the cells within any given tumor, they have the seeming “immortal” ability to self renew, are capable of continuous differentiation, are resistant to conventional chemotherapeutic agents, and are tumorigenic, i.e. are capable of “splitting off” to create new tumor colonies. Clearly, the cancer stem cells within a tumor must be destroyed if cancer treatment is to affect a lasting cure.
The new study titled, “6-Shogaol Inhibits Breast Cancer Cells and Stem Cell-Like Spheroids by Modulation of Notch Signaling Pathway and Induction of Autophagic Cell Death,” identified powerful anti-cancer stem cell activity in 6-shogaol, a pungent constituent of ginger produced when the root is either dried or cooked. The study also found that the cancer-destroying effects occurred at concentrations that were non-toxic to non-cancerous cells – a crucial difference from conventional cancer treatments that do not exhibit this kind of selective cytotoxicity and therefore can do great harm to the patient.
The authors of the study further affirm these points:
“Cancer stem cells pose serious obstacle to cancer therapy as they can be responsible for poor prognosis and tumour relapse. To add into the misery, very few chemotherapeutic compounds show promise to kill these cells. Several researchers have shown that cancer stem cells are resistant to paclitaxel, doxorubicin, 5-fluorouracil, and platinum drugs [8, 16]. CSCs are thus an almost unreachable population in tumours for chemotherapy. Therefore any compound, that shows promise towards cancer stem cells, is a highly desirable step towards cancer treatment and should be followed up for further development.”
The researchers identified a variety of ways by which 6-shagoal targets breast cancer:
  • It reduces the expression of CD44/CD24 cancer stem cell surface markers in breast cancer spheroids (3-dimensional cultures of cells modeling stem cell like cancer)
  • It significantly affects the cell cycle, resulting in increased cancer cell death
  • It induces programmed cell death primarily through the induction of autophagy, with apoptosis a secondary inducer
  • It inhibits breast cancer spheroid formation by altering Notch signaling pathway through γ-secretase inhibition.
  • It exhibits cytotoxicity (cell killing properties) against monolayer (1-dimensional cancer model) and spheroid cells (3-dimensional cancer model)
It was in evaluating the last mode of 6-shagoal’s chemotherapeutic activity and comparing it to the activity of the conventional chemotherapeutic agent taxol that the researchers discovered an astounding difference. Whereas taxol exhibited clear cytotoxicity in the one-dimensional (flat) monolayer experimental model, it had virtually no effect on the spheroid model, which is a more “real world” model reflecting the 3-dimensionality of tumors and their stem cell subpopulations. Amazingly, this held true even when the concentration of taxol was increased by four orders of magnitude:
“In contrast [to 6-shagoal], taxol, even though was highly active in monolayer cells, did not show activity against the spheroids even at 10000 fold higher concentration compared to 6-shogoal.”
This is a highly significant finding, as it affirms a common theme in cancer research that acknowledges the primarily role of cancer stem cells: namely, while conventional techniques like surgery, radiation, and chemotherapy are effective at reducing a tumor’s size, sometimes to the point where it is “debulked,” burned,” or “poisoned” out of the body even below the threshold of re-detection, the appearance of “winning the battle” often comes at a steep price, as ultimately the cancer stem cell population regrows the tumors, now with increased vengeance and metastastic invasiveness, resulting in the cancer “winning the war.”
The monolayer model, which does not account for the complex immunity of actual cancer stem-cell based tumors against chemoagents like taxol, represents the old preclinical model of testing cancer treatments. The spheroid model, on the other hand, clearly shows that even 10,000 times higher concentrations of taxol are not capable of beating this ginger component at selectively targeting the root cause of the tumor malignancy.
In their concluding remarks, the authors point out a hugely important distinction between natural anti-cancer agents and conventional ones that have only been introduced in the past half century or so, namely, “Dietary compounds are welcome options for human diseases due to their time-tested acceptability by human bodies.”  
Unlike modern synthetically produced and patented chemicals, ginger, curcumin, green tea, and hundreds of other compounds naturally found in the human diet, have been “time-tested” as acceptable to the human body in the largest and longest running “clinical trials” known: the tens of thousands of years of direct human experience, spanning thousands of different cultures from around the world, that constitute human prehistory. These experientially-based “trials” are validated not by RCTs, or a peer-reviewed publication process, but by the fact that we all made it through this incalculably vast span of time to be alive here today. Consider also that if our ancestors made the wrong dietary choice by simply mistaking an edible berry for a poisonous one, the consequences could be deadly. This places even greater emphasis on how the “time testing” of dietary compounds was not an academic but a life-death affair, and by implication, how the information contained within various cultural traditions as “recipes” passed down from generation to generation are “epigenetic inheritance systems” no less important to our health and optimal gene expression as the DNA in our own bodies.
Ultimately, this new study adds to a growing body of research indicating that cancer stem cell targeting approaches using natural substances present in the human diet for thousands of years are far superior chemotherapy and radiation, both of which actually increase the relative populations of cancer stem cells versus non-tumorigenic ones. For further reading on ginger’s anti-cancer properties, consult our Ginger Research database. Also, you can use our Cancer Research Health Guide for thousands of studies and articles about natural healing approaches for cancer.
Sayer Ji is an author and educator, a Board of Governor for the National Health Federation, Steering Committee Member of the Global GMO Free Coalition (GGFC), and founder of Greenmedinfo.com. Join their free newsletter here.Sayer Ji

Stop Breast Cancer Spreading to the Bone

Manchester scientist to investigate how to stop breast cancer spreading to the bone

A leading Manchester scientist has been awarded a grant of over £195,000 by research charity Breast Cancer Now to investigate whether certain drugs could stop breast cancer spreading to the bone.

Friday 13 October 2017 Research Rob Clarke and Rachel Eyre

Rob Clarke and Rachel Eyre

Dr Robert Clarke and Dr Rachel Eyre

The news comes on Secondary Breast Cancer Awareness Day (Friday 13 October 2017), as Breast Cancer Now announces more than £700,000 of funding across the UK for research specifically targeting secondary breast cancer – where the disease has spread to another part of the body.

If breast cancer spreads – known as secondary or metastatic breast cancer – it becomes incurable, and almost all of the 11,500 women that die as a result of breast cancer each year in the UK will have seen their cancer spread. More than 2,000 women in Greater Manchester are diagnosed with breast cancer every year, and over 400 women in the region die from the disease each year.1

The bone is one of the most common and least treatable places for breast cancer to spread to. Secondary tumours in the bone can cause joint pain as well as debilitating fractures that often require surgery at a time that is already difficult for patients.

Special types of cells, called breast cancer stem cells (BCSCs), are thought to be responsible for breast cancer coming back after treatment. These cells are able to travel to distant locations – such as the bone – where they can remain inactive, not being affected by therapy, for long periods of time.

Dr Robert Clarke and Dr Rachel Eyre's work
Dr Robert Clarke, based at the Breast Cancer Now Research Unit at the University of Manchester, has been investigating why BCSCs so often spread to the bone, and how the bone environment allows them to survive and grow to form secondary tumours. His previous studies revealed that a molecule inside bones called interleukin 1-beta (IL-1β) triggers a survival mechanism within BCSCs.

Dr Clarke and researcher Dr Rachel Eyre will investigate how IL-1β helps BCSCs migrate to the bone and survive once there. Using BCSCs grown in the lab and in mice, the team of scientists will explore whether drugs that block IL-1β – and the survival mechanism it triggers – could be used to stop secondary tumours forming in the bone.

Next, the team will cultivate BCSCs in bone samples donated by hip replacement patients from the Manchester Royal Infirmary, to replicate what happens when breast cancer spreads to the bones. They will investigate how BCSCs are able to colonise the bone environment, and whether blocking IL-1β could affect their ability to do so.

Kathleen Moss, 61, from Oldham, initially underwent treatment for primary breast cancer in 2011, but last year, she sadly learned that her cancer had spread, when a painful hip alerted her to metastases in her bones and liver.

Kathleen Moss

Kathleen is currently taking Herceptin and Perjeta, which she will continue to take until her breast cancer progresses. She said:

“Hearing the diagnosis of ‘secondary’ was a real game-changer for me. When my aggressive breast cancer came back after four years, I went from happily "cancer free" to living with cancer on a daily basis: morphine tablets to contain bone pain twice a day, chemotherapy every three weeks, and three-monthly CT and MRI scans.

Side effects make my feet and fingers permanently numb, my nose bleeds, my hair thins and my fingernails break and fatigue is crippling. Almost as hard to bear is the effect on my outgoing and happy husband, who has battled with depression since my diagnosis. Our plans for the future have telescoped into three month segments, always mindful that my secondary breast cancer is incurable, only contained with treatment.

“The first place my cancer spread was to my bones. It was scary going from a lively 58 year old to someone who had trouble walking. Knowing that Dr Clarke and his team are working on a way to stop this spread in other breast cancer patients gives me hope. Although his research won't help me, I hope it can help thousands of others. I wouldn't wish this pain and uncertainty on other families.”

Dr Robert Clarke, Reader in Breast Biology at the University of Manchester, said:

“Rachel and I are very excited to be starting this Breast Cancer Now-funded project. We believe that we have discovered a key factor promoting spread to the bone marrow, which is very common in breast cancer. This funding from Breast Cancer Now will enable us to discover whether we can use drugs to target and prevent breast cancer spread in experimental systems, which is an important step to gather sufficient supporting evidence for clinical trials to take place.”

Dr Richard Berks, Senior Research Communications Officer at Breast Cancer Now, said:

“Drugs that block IL-1β are already used to treat rheumatoid arthritis, and so if this approach is shown to be effective in breast cancer, it could allow patients with secondary breast cancer in the bone to access these drugs much more quickly.

“Our ambition is that by 2050, everyone who develops breast cancer will live. But if we are to achieve this, we desperately need to raise funds for research to find ways to stop the disease spreading.

“This project could help bring us one step closer to our 2050 vision, and we’d like to thank our supporters in Manchester who continue to help make potentially life-saving research like this possible.”


1. Source of information: Local incidence and mortality survival statistics were provided on request by Public Health England, April 2017 – similar data are available from cancerdata.nhs.uk Figures are based upon averages for 2012-2014.
2. Article Source: Breastcancernow.org